Pamela B Davis M.D., Ph.D. BRTT Principle Investigator

Chief of Pediatric Pulmonology Sr. Associate Dean of Research Professor Pediatric Pulmonology Physiology & Biophysics Molecular Biology & Microbiology pbd@case.edu Biomedical Research Building 831 Case School of Medicine 10900 Euclid Ave, Cleveland (216) 368 4370 Phone Davis website Davis Biosketch

Dr. Davis has been continuously funded by the National Institutes of Health via the R01 mechanism since 1981, and has held multiple research project grants from the Cystic Fibrosis Foundation.  This work focuses on the development of lung disease in cystic fibrosis (CF), particularly infection and inflammation, and also on gene transfer and targeted therapeutic proteins for therapy of CF.  She has conducted basic laboratory research, and has also run clinical trials, holding an investigator-initiated IND for use of ibuprofen in CF: her work has moved from the bench to the bedside and back.   She has catalyzed and led a research program in cystic fibrosis for years, as the Principal Investigator of a P30 grant in Cystic Fibrosis (NIDDK) since 1986, a T32 (NIH training grant from NHLBI) since 1988, and a Research Development Program grant from the Cystic Fibrosis Foundation since 1987.   Her work led to six issued patents and others that are pending.  These patents address the targeting of therapeutic agents to particular tissues or sites (e.g., the apical surface of airway epithelial cells), and with the compaction of DNA for delivery to cells and into the nucleus.  Dr. Davis’ patents were licensed by CWRU to Copernicus Therapeutics, Inc.( Cleveland OH ), which has taken DNA nanoparticles for gene transfer through Phase I clinical trial.  Some of her patents are sublicensed to Arizeke, Inc. ( San Diego , CA ), a company focused on the use of fusion proteins targeting the polymeric immunoglobulin receptor for therapeutic purposes in the lung.  Dr. Davis serves on the scientific advisory board of Arizeke.  Thus, she has experience in basic research, clinical research including clinical trials and the FDA,  generation of patentable ideas, their commercial development, and (at a distance) their testing in the clinic.