Project One:
DNA Nanoparticle Therapeutic for Hemophilia
Mark J. Cooper, M.D.,
Copernicus Therapeutics, Inc.
Notice: These publications (studies or reports) were prepared under a grant from the State of Ohio, Department of Development. The content reflects the views of Case Western Reserve University and does not nesessarily reflect the veiws of the State of Ohio, Department of Development or the Third Frontieer Commission.
Ziady, A.G., Gedeon, C.R., Miller, T., Quan, W., Payne, J.M., Hyatt, S.L., Fink, T.L., Muhammad, O., Oette, S., Kowalczyk, T., Pasumarthy, M.K., Moen, R.C., Cooper, M.J., and
"Transfection of airway epithelium by stable PEGylated poly-L-lysine DNA nanoparticles"
In Vivo. Mol. Ther., 8:936-947
Ziady, A.G., Gedeon, C.R., Muhammad, O., Oette, S.M., Fink, T.L., Quan, W., Kowalczyk, T.H., Hyatt, S.L., Peischl, A., Seng, J.E., Moen, R.C., Cooper, M.J., and Davis, P.B: (2003)
"Minimal toxicity of stabilized compacted DNA nanoparticles in the murine lung"
Mol. Ther., 8:948-956
Konstan, M.W., Davis, P.B., Wagener, J.S., Hilliard, K.A., Stern, R.C., Milgram, L.J.H., Kowalczyk, T.H., Hyatt, S.L., Fink, T.L., Gedeon, C.R., Oette, S.M., Payne, J.M., Muhammad, O., Ziady, A.G., Moen, R.C., and Cooper, M.J.
"Compacted DNA nanoparticles administered to the nasal mucosa of cystic fibrosis subjects are safe and demonstrate partial to complete CFTR reconstitution"
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Hum Gene Ther. 15(12):1255-69, 2004
Liu, G., Li, D.-S., Pasumarthy, M.K., Kowalczyk, T.H., Gedeon, C.R., Hyatt, S.L., Payne, J.M., Miller, T.J., Brunovskis, P., Fink, T.L., Muhammad, O., Moen, R.C., Hanson, R.W., and Cooper, M.J. (2003)
"Nanoparticles of compacted DNA transfect postmitotic cells"
J. Biol. Chem. 278:32578-32586
Ziady, A.G., Kim, J., Colla, J., and Davis, P.B. (2004)
"Defining strategies to extend duration of gene expression from targeted compacted DNA vectors"
Gene Ther11:1378-90, 2004
Vermeer, C., Hendrix, H., and Daemen, M. (1982)
"Vitamin K-dependent carboxylases from non-hepatic tissues
FEBS Lett. 148(2):317-320
Vermeer, C. (1986)
"Comparison between hepatic and nonhepatic vitamin K-dependent carboxylase"
Haemostasis. 16(3-4):239-245
"Vitamin K dependent carboxylation of glutamate residues to gamma-carboxyglutamate in microsomes from spleen and testes: comparison with liver, lung, and kidney"
Biochemistry. 22(5):1077-1082