Project Two References:

Targeting DNA nanoparticles to the Serpin-enzyme complex receptor.

Assem Ziady, Ph.D.
School of Medicine, Case Western Reserve University


Notice: These publications (studies or reports) were prepared under a grant from the State of Ohio, Department of Development. The content reflects the views of Case Western Reserve University and does not nesessarily reflect the veiws of the State of Ohio, Department of Development or the Third Frontieer Commission.


A.G. Ziady, J. Kim, J. Colla, and P.B. Davis
"Defining strategies to extend duration of gene expression from targeted compacted DNA vectors"
Gene Therapy.11(18):1378-1390, 2004

Konstan MW, Davis PB, Wagener JS, Hilliard KA, Stern RC, Milgram LJ, Kowalczyk TH, Hyatt SL, Fink TL, Gedeon CR, Oette SM, Payne JM, Muhammad O, Ziady AG, Moen RC, Cooper MJ
"Compacted DNA nanoparticles administered to the nasal mucosa of cystic fibrosis subjects are safe and demonstrate partial to complete cystic fibrosis transmembrane regulator reconstitution"
Hum Gene Ther. 15(12):1255-69, 2004

Rhee, M and Davis PB
"Rapid transit of C105Y to the nucleus in nondividing cells"
Abstract sub to Cell Biology 2004

A.G. Ziady, C.R. Gedeon, O. Muhammad, V. Stillwell, S. Oette, T. Fink, W. Quan, T. Kowalczyk, S.L. Hyatt, A. Peischl, J.E. Seng, R. Moen, M.J. Cooper, P.B. Davis
"Minimal toxicity of stabilized compacted DNA in the murine lung" 
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Molecular Therapy.  8(6): 948-956, 2003

A.G. Ziady, C.R. Gedeon, T. Miller, W. Quan, J.M. Payne, S.L. Hyatt, T. Fink, O. Muhammad, S. Oette, T. Kowalczyk, M.K. Pasumarthy, R. Moen, M.J. Cooper, P.B. Davis
"Transfection of Airway Epithelium by Stable PEGylated Poly-L-lysine DNA Nanoparticles In Vivo"
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Molecular Therapy.  8(6): 936-947, 2003

Liu G, Li D, Pasumarthy MK, Kowalczyk TH, Gedeon CR, Hyatt SL, Payne JM, Miller TJ, Brunovskis P, Fink TL, Muhammad O, Moen RC, Hanson RW, Cooper MJ.
"Nanoparticles of compacted DNA transfect postmitotic cells"
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J Biol Chem. 278(35):32578-86, 2003

Funke M and Davis PB 
"Evaluating the intracellular vesicular trafficking pathways responsible for the dleivery of SECR-R targeted compacted DNA complexes to the nucleus"
Ped Pulmonol suppl25, p. 263, 2003

Ziady AG, Kelley TJ, Milliken E, Ferkol T, Davis PB
"Functional evidence of CFTR gene transfer in nasal epithelium of cystic fibrosis mice in vivo following luminal application of DNA complexes targeted to the serpin-enzyme complex receptor"
Molecular Therapy 5(4):413-9, 2002

Patel S, Zhang X, Collins L, Fabre JW. 
"A small, synthetic peptide for gene delivery via the serpin-enzyme complex receptor"
J Gene Med. 3(3):271-9, 2001

Wu P, Xiao W, Conlon T, Hughes J, Agbandje-McKenna M, Ferkol T, Flotte T, Muzyczka N. 
"Mutational analysis of the adeno-associated virus type 2 (AAV2) capsid gene and construction of AAV2 vectors with altered tropism"
J Virol. 2000 Sep;74(18):8635-47.

Fisher KD, Ulbrich K, Subr V, Ward CM, Mautner V, Blakey D, Seymour LW. 
"A versatile system for receptor-mediated gene delivery permits increased entry of DNA into target cells, enhanced delivery to the nucleus and elevated rates of transgene expression"
Gene Ther. 7(15):1337-43, 2000

Ziady AG, Ferkol T, Dawson DV, Perlmutter DH, Davis PB
"Chain length of the polylysine in receptor-targeted gene transfer complexes affects duration of reporter gene expression both in vitro and in vivo"
Journal of Biological Chemistry 274(8):4908-16, 1999

Ziady AG, Ferkol T, Gerken T, Dawson DV, Perlmutter DH, Davis PB
"Ligand substitution of receptor targeted DNA complexes affects gene transfer into hepatoma cells"
Gene Therapy 5(12):1685-97, 1998

Ziady AG, Perales JC, Ferkol T, Gerken T, Beegen H, Perlmutter DH, Davis PB
"Gene transfer into hepatoma cell lines via the serpin enzyme complex receptor"
Am J Physiol. 273(2 Pt 1):G545-52, 1997

Zheng NJ, Rau G, Hazelwood CF, Rau C. 
"High-resolution, real-space imaging of conformational structures of poly-L-proline helixes"
Scanning Microsc. 5(3):631-5; discussion 635-6, 1991