Project Five:
"Smart" MRI Detection of Therapeutics Targeted to Metastatic Breast Tumors
Marty Pagel, Ph.D.
Jinming Gao, Ph.D.
Clemens Burda, Ph.D. Department of Chemistry
Malcolm E. Kenney, Ph.D. Department of Chemistry
Case Western Reserve University
Notice: These publications (studies or reports) were prepared under a grant from the State of Ohio, Department of Development. The content reflects the views of Case Western Reserve University and does not nesessarily reflect the veiws of the State of Ohio, Department of Development or the Third Frontieer Commission.
Greish K, Fang J, Inutsuka T, Nagamitsu A, Maeda H
"Macromolecular Therapeutics: Advantages and Prospects with Special Emphasis on Solid Tumour Targeting"
Clin. Pharmacokinet., 2003, 42(13):1089-1005
Ulbrich K, Subr V, Strohalm J, Plocova D, Jelinkova M, Rihova B
"Polymeric drugs based on conjugates of synthetic and natural macromolecules I. Synthesis and physio-chemical charactertization"
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Vasey PA, Kaye SB, Morrison R, Twelves C, Wilson P, Duncan R, Thomson AH, Murray LS, Hilditch TE, Murray T, Burtles S, Fraier D, Frigerio E, Cassidy J
"Phase I clinical and pharmacokinetic study of PK1 [N-(2-hydroxypropyl)methacrylamide copolymer doxorubicin]: first member of a new class of chemotherapeutic agents – drug-polymer conjugates"
Clin. Cancer Res., 1999, 5:83-94
Peterson CM, Shiah JG, Sun Y, Kopeckova P, Minko T, Straight RC, Kopecek J
"HPMA copolymer delivery of chemotherapy and photodynamic therapy in ovarian cancer"
Adv. Exp. Med. Biol., 2003, 519:101-123
Vexler VS, Clement O, Schmitt-Willich H, Brasch RC
"Effect of Varying the Molecular Weight of the MR Contrast Agent Gd-DTPA-Polylysine on Blood Pharmacokinetics and Enhancement Patterns"
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Ward KM, Aletras AH, Balaban RS
"A New Class of Contrast Agents for MRI Based on Proton Chemical Exchange Dependent Saturation Transfer (CEST)"
J. Magn. Reson., 2000, 143:79-87
Zhang S, Merritt M,
"PARACEST agents: modulating MRI contrast via wter proton exchange"
Acc. Chem. Res., 2003, 36(10):783-790
Aime S, Barge A, Delli Castelli D, Fedeli F, Mortillaro A, Nielsen FU, Terreno E
"Paramagnetic Lanthanide(III) Complexes as pH-Sensitive Chemical Exchange Saturation Transfer (CEST) Contrast Agents for MRI Applications"
Magn. Reson. Med., 47:639-648, 2002
Rihova B, Kubackova K
"Clinical implications of N-(2-hydroxypropyl)methacrylamide copolymers"
Curr. Pharm. Biotechnol., 2003, 4(5):311-322
Seymour LW, Duncan R, Strhalm J, Kopecek J
"Effect of molecular weight (Mw) of N-(2-hydroxylpropyl)methacrylamide copolymers on body distribution and rate of excretion after subcutaneous, intraperitoneal, and intravenous administration to rats"
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Reynolds T
"Polymers help guide cancer drugs to tumor targets—and keep them there"
J. Natl. Cancer Inst., 1995, 87(21):1582-1584
DelaFlor-Weiss E, Uziely B, Muggia FM
"Protracted drug infusions from cancer treatment: an appraisal of 5-fluorouracil, doxorubicin and platinums"
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Soule HD, Vazquez J, Long A, Albert S, Brennan M
"A human cell line from a pleural effusion derived from a breast carcinoma"
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Cailleau R, Young R, Olivé M, Reeves Jr WJ
"Breast tumor cell lines from pleural effusions"
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Lacroix M, Leclercq G
"Relevance of breast cancer lines as models for breast tumors: an update"
Breast Cancer Res. Treat., 2004, 83:249-289
Zhang L, Kharbanda S, Chen D, Bullocks J, Miller DL, Ding IY, Hanfelt J, McLeskey SW, Kern FG
"MCF-7 breast carcinoma cells overexpressing FGF-1 form vascularized, metastatic tumors in ovariectomized or tamoxifen-treated nude mice"
Oncogene, 1997, 15(17):2093-2108
Lee TH, Avraham HK, Jiang S, Avraham S
"Vascular endothelial growth factor modulates the transendothelial migration of MDA-MB-231 breast cancer cells through regulation of brain microvascular endothelial cell permeability"
J. Biol. Chem., 2003, 278(7):5277-5284
John A, Tuszynski G
"The role of matrix metallorproteinases in tumor angiogenesis and tumor metastasis"
Pathol. Oncol. Res., 2001, 7(1):14-23
Di Nezza LA, Misajon A, Zjang J, Jobling T, Quinn MA, Östör AG, Nie G, Lopata A, Salamonsen LA
"Presence of active gelatinases in endometrial carcinoma and correlation of matrix metalloproteinase expression with increasing tumor grade and invasion"
Cancer, 2002, 94(5):1466-1475
Nakopoulou L, Tsirmpa I, Alexandrou P, Louvrou A, Ampela C, Markaki S, Davaris PS
"MMP-2 protein in invasive breast cancer and the impact of MMP-2/TIMP-2 phenotype on overall survival"
Breast Cancer Res. Treat., 2003, 77(2):145-155
Hanemaaijr R, Verheijen JH, Maguire TM, Visser H, Toet K, McDermott E, O’Higgins N, Duffy MJ
"Increased gelatinase-A and gelatinase-B activities in malignant vs. benign breast tumors"
Int. J. Cancer, 2000, 86:204-207
Tester AM, Ruangpanit N, Anderson RL, Thompson EW
"MMP-9 secretion and MMP-2 activation distinguish invasive and metastatic sublines of a mouse mammary carcinoma system showing epithelial-mesenchymal transition traits"
Clin. Exp. Met., 2001, 18:553-560
Pagel MD, Baldwin SJ, O’Neal JM, Ornberg RL, Davis TW, Kotyk JK
"Merits of Multiple Contrast Agents and Pixel-by-Pixel Analyses for Detection of Early Changes in Vascular Permabilities in Murine Tumor Models Following Drug Therapy and/or Radiation Therapy"
Proc. ISMRM, 2003, 11:1250
"Synergy between celecoxib and radiotherapy results from inhibition of COX-2 derived PGE2, a survival factor for tumor and associated vasculature"
Cancer Res., 2004, 64:279-285
Qian F, Stowe N, Liu EH, Saidel GM, Gao JM
"Quantification of in vivo doxorubicin transport from PLGA millirods in thermoablated rat livers"
J. Cont. Rel., 2003, 91:157-166
Qian F, Stowe N, Saidel GM, Gao J
"Comparison of doxorubicin concentration profiles in radiofrequency-ablated rat livers from sustained- and dual-release PLGA millirods"
Pharm. Res., 2004, 21:394-399